Lion’s Mane contains over 70 bioactive ingredients and can be considered one of the most interesting mushrooms for gaining and maintaining good health. Very few mushrooms cover such a wide spectrum of therapeutic potential.

Oriveda's lossless 1:1 hot water extract contains the full Lion's Mane fruiting body in a bioavailable form. Nothing was filtered out, both soluble and insoluble bioactives are still present in their natural synergy. In this case 'lossless' is crucial because we want the product to be 100% in line with the existing clinical research.

Three of the existing human case studies were done with non-extracted dried Lion's Mane fruiting body powder; by extracting this dried powder (like we did) the bioavailability / potential effect increases ± 4 - 10 times (See our FAQ), and the required dosage drops from ± 2 - 3 grams daily to ± 600 - 900 mg daily.

Concentrated water extracts are not in line with Lion's Mane research. "Concentrated" means insoluble matter is filtered out, leaving only water-soluble matter.

However, unlike most other mushrooms Lion's Mane contains mainly insoluble beta-glucan. This will be filtered out, together with the NGF-inducing terpenes (hericenones), sterols and other potentially interesting bioactive compounds; none of these are water-soluble. Test results prove the lack of potency (10-15% of beta-glucans instead of over 40%). This makes a concentrated water extract a waste of money.

In case of Lion's Mane a 1:1 lossless hot water extracted fruiting body is the best option.

Oriveda's pharma-grade mycelium extract is the worlds first premium alcohol extract based on pure -starch-free- liquid-grown mycelium. The emphasis is on the alcohol-soluble terpenes / terpenoids; i.p. a group of diterpenes known as erinacines. The most recent clinical trials were all using pure mycelium extracts.

Erinacines are seen as the main NGF-inducers in Lion's Mane. They are only found in the mycelium. We have used a custom composition (a nutrients formula) for the liquid substrate in which the mycelium is growing; its purpose is to increase the production of erinacines, i.p. erinacine A. See our FAQ for additional details.

The final products contain no alcohol.

For in-depth information about this mushroom and functional mushrooms in general check the educational section on our main portal for some useful links.

Check our certified objective lab test reports here.
For extensive FAQ visit this page.

• Produced in full compliance with the following quality standards :
• ISO 9001
• ISO 22000
• HACCP
• cGMP
• and also
• Halal
• Koosjer
• USDA organic (EcoCert)

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According to research* the average amount of beta-glucans in wild-harvested Chaga is around 10-14% when properly extracted.

Oriveda's Chaga extract contains significantly more: over 20 % of bioactive beta-glucan.

This high percentage is possible because we use advanced purification techniques, removing useless matter such as wood from the raw Chaga. Most people don't know that only ± 10% of the Chaga conk is actually 'mushroom', the rest is mainly useless wood.**

By removing the 'non-Chaga' matter the potency increases significantly. Our lab test reports confirm this. The final product offers way better value for money than the crude extracts available elsewhere.

The final product contains no alcohol.

For in-depth information about this mushroom and functional mushrooms in general check the educational section on our main portal for some useful links.

Check our certified objective lab test reports here.
For extensive FAQ visit this page.

• Produced in full compliance with the following quality standards :
• ISO 9001
• ISO 22000
• HACCP
• cGMP
• and also
• Halal
• Koosjer
• USDA organic (EcoCert)

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*http://www.sciencedirect.com/science/article/pii/S0023643807001430 **Chemical characterization and biological activity of Chaga (2015)

You may have heard about 'PSK' and 'PSP'. These are composite molecular structures consisting of beta-glucans linked to a protein, aka 'proteo-glycans' or 'glyco-proteins'. These proteo-glycans are also found in other mushrooms such as Reishi, Maitake and ABM and are very bioactive.

'PSP' is an improved version of the Japanese PSK, a patented Turkey Tail mycelium extract developed in the 1970's but now considered outdated and no longer in production because PSP is significantly more potent, not protected by a patent and cheaper to produce. Oriveda's PSP-50 is identical to the original PSP as it was developed in China, over 35 years ago.

Oriveda's PSP-50 has been cultivated and extracted using the original methods. The only difference is a significant higher purity due to the more advanced 21st century pharmaceutical techniques. Only pure COV-1® mycelium (the 'roots' of the mushroom) was used for Oriveda's extract, having the highest level of the desired bioactives. Our objective lab reports confirm the purity and potency of this extract.

Extracted using hot water followed by alcohol precipitation - the main bioactives are water-solubles with a high molecular weight according to research. Alcohol precipitation is a purification process. It removes useless matter and low molecular weight compounds and thus increases the concentration of the marker compounds in the extract. The final product contains no alcohol.

For in-depth information about this mushroom and functional mushrooms in general check the educational section on our main portal for some useful links.

Check our certified objective lab test reports here.
For extensive FAQ visit this page.

• Produced in full compliance with the following quality standards :
• ISO 9001
• ISO 22000
• HACCP
• cGMP
• and also
• Halal
• Koosjer
• USDA organic (EcoCert)

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TL;DR: If you use Google to look for additional details on Maitake's therapeutic potential - you will read about the 'D-Fraction®', the 'MD-Fraction' and others.

Based on the existing facts we can claim Oriveda's Grifolan® is at least equal to, if not more potent than the best of the current commercially available Maitake products such as D-Fraction® and MaiTakeGold 404®. Apart from that, the value for money is significantly better.

• The D-fraction is originally a term coined in the 1980s; it referred then to a purified -fractionated- beta-glucan, bonded with a protein; a so-called 'proteoglycan' similar to what is present in Turkey Tail (PSP) and Reishi. This particular fraction showed a lot of promise because of its anti-tumor potential.

• Unfortunately, neither this product nor its successor, the MD-fraction (a more pure version of the D-Fraction, patented in 1997) is for sale in its undiluted pure form; the production costs are probably too high (it's a 200 : 1 extract) and the fractionating process is too complex for mass-production.

• Although the manufacturers prefer to keep the details as vague as possible (marketing reasons), here are some -verifiable- facts:

• Apart from being a research-term, 'D-Fraction®' is a trademark*, registered in 1995. Products sold with the name 'D-Fraction®' contain, according to the label 'PD-Fraction®*' (which stands for 'Pre-D-Fraction'). It is unclear what this is. It is not the D-fraction from the research.

• The commercial supplement 'D-Fraction®' has been tested against another Maitake supplement, MaitakeGold 404®* (MTG), containing (according to that same test rapport and a follow-up) a diluted version of the patented MD-Fraction. The test involved many immunological parameters. MTG scored significantly better in all tests.

• MTG is standardised for ≥ 20% beta-glucans (though not on the label). Nothing else.
The glucan/protein ratio is not revealed, although this would be an easy and cheap way to authenticate the product as being pure (the ratio should be between ± 2 : 1 (= d-fraction purity) all the way to 99 : 1 (= md-fraction purity) according to the patents).

• MTG is sold only in liquid form; 1 gram of extract dissolved in 30 ml of liquid. The recommended daily dosage is 8 - 16 drops daily, which equals 19 - 77 mg MTG. The optimal dosage of this extract is, according to independent research (a clinical trial), ± 7 mg/kg bodyweight/day (e.g. a 60 kg person should take ± 420mg daily), which is significantly more.

• Oriveda's Grifolan® is standarised for ≥ 40 % beta-glucans and can deliver the recommended daily dosage for optimal immunological effect easily. Because the extract used in the research was more pure than any commercially available product, the dosage should be adjusted accordingly: we recommend at least 3 - 6 capsules per day (each with ≥ 160 mg beta-glucans) if maximum therapeutic potential is needed. (The standard dose for normal immune support is 2 capsules daily.)

Grifolan® has been extracted using hot water followed by alcohol precipitation - the main bioactives are water-soluble beta-glucans and proteoglycans with a high molecular weight, according to research.

Alcohol precipitation is a purification process. It removes useless matter and low molecular weight compounds and thus increases the concentration of bioactives in the final product. The final product contains no alcohol.

For in-depth information about this mushroom and functional mushrooms in general check the educational section on our main portal for some useful links.

Check our certified objective lab test reports here.
For extensive FAQ visit this page.

• Produced in full compliance with the following quality standards :
• ISO 9001
• ISO 22000
• HACCP
• cGMP
• and also
• Halal
• Koosjer
• USDA organic (EcoCert)

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Beta-glucan is always important as a marker compound, but it is not Cordyceps-specific and it is not responsible for the Cordyceps-specific properties. Beta-glucan supports the immune function.

As said the C+ blend has been optimised for Cordyceps-specific compounds such as cordycepin. When compared against run-of-the-mill Cordyceps products the revitalising potential will be much higher, together with better kidney- and lung-protective properties.

Cordycepin mimics ATP (Adenosine-Tri-Phosphate). ATP is the most important energy provider in our body; it must be present for muscles to contract. To be blunt: no ATP means no heartbeat!

Among the effects of ATP are increased blood flow and vasodilation (opening up your blood vessels); and increasing e.g. the ability to absorb oxygen in the blood stream via the lungs. This results in more energy and vitality; important for endurance athletes and the elderly.

ATP production in the body is decreasing with age, and research showed that supplementation with synthetic ATP has no effect. Now this is where it gets interesting; recent research papers confirm the old belief that Cordyceps improves vitality. Put in scientific terminology: it enhances cellular energy in the form of ATP.

Cordyceps supplementation with a high level of cordycepin will help to restore and maintain vitality and increase physical endurance. It also restores normal testosteron levels if these are too low.

The CS-4 mycelium strain of Cordyceps sinensis is the most researched form (over 98% of all research) and has in fact better properties than wild natural Cordyceps in terms of the presence of nucleosides such as adenosine.

In Cordyceps militaris the cordycepin nucleoside has been the main subject of research in the past decades. It is an important bioactive compound and a marker for Cordyceps militaris' quality.

Oriveda C+ blends 66.6 % Cordyceps CS-4 mycelium extract and 33.4% Cordyceps militaris (CM) fruiting body extract into one product. The level of cordycepin is guaranteed to be > 1%, making it the most potent Cordyceps extract currently on the market, outclassing the best of the rest at least 3 times.

Extracted using hot water followed by alcohol precipitation - the main bioactives are water-solubles with a high molecular weight according to research.

Alcohol precipitation is a purification process. It removes useless matter and low molecular weight compounds and thus increases the concentration of bioactives in the final product. The final product contains no alcohol.

For in-depth information about this mushroom and functional mushrooms in general check the educational section on our main portal for some useful links.

Check our certified objective lab test reports here.
For extensive FAQ visit this page.

• Produced in full compliance with the following quality standards :
• ISO 9001
• ISO 22000
• HACCP
• cGMP
• and also
• Halal
• Koosjer
• USDA organic (EcoCert)

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Objectively speaking, this is the best mushroom blend in the market and the only one that makes sense from a logical point of view.

Not 'a lot of mushrooms for the price of one' (which is nonsensical - everything will be underdosed) but a combination of their main marker compounds (several types of beta-glucan, both structurally different and soluble / insoluble variations), the powerful cordycepin compound and including the three main NGF-inducing mushrooms (Lion's Mane, Cordyceps and Tiger Milk), increasing the potential for synergy to the max.

This blend brings you everything needed to rebalance your body and brain.

For in-depth information about this mushroom and functional mushrooms in general check the educational section on our main portal for some useful links.

Check our certified objective lab test reports here.
For extensive FAQ visit this page.

• Produced in full compliance with the following quality standards :
• ISO 9001
• ISO 22000
• HACCP
• cGMP
• and also
• Halal
• Koosjer
• USDA organic (EcoCert)

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What sets functional mushrooms apart from pharmaceuticals and what makes them particularly effective is the synergistic effect of the combined bioactives (mainly Beta-Glucans, glycoproteins/proteo-glycans, polyphenols and Ganoderic Acids [-a type of triterpenes-] ). Functional mushrooms in general have no side effects either.

In the case of mushrooms extraction defines the therapeutic potential, since we cannot digest non-extracted mushrooms properly. See this -highly recommended!- link for more details.

Extraction is essential for an actual therapeutic effect, and dual extraction is the best option in the case of Reishi - it ensures both water-solubles and insolubles are present in a bioavailable form.

For in-depth information about this mushroom and functional mushrooms in general check the educational section on our main portal for some useful links.

Check our certified objective lab test reports here.
For extensive FAQ visit this page.

• Produced in full compliance with the following quality standards :
• ISO 9001
• ISO 22000
• HACCP
• cGMP
• and also
• Halal
• Koosjer
• USDA organic (EcoCert)

Close